Syntometrine Injection SPC Summary
Quick summary: Syntometrine injection is a combination obstetric medicine containing ergometrine maleate and oxytocin. It is used in the management of the third stage of labour and to help reduce postpartum bleeding. This summary...
This content is for educational purposes only and does not replace medical advice, diagnosis or treatment from a qualified healthcare professional.
Quick summary: Syntometrine injection is a combination obstetric medicine containing ergometrine maleate and oxytocin. It is used in the management of the third stage of labour and to help reduce postpartum bleeding. This summary covers the main SPC-style points, including use, precautions, side effects, and common questions.
Medical disclaimer: This article is for general information only and does not replace the official product information, local clinical guidance, or advice from a qualified healthcare professional. Always check the latest SPC or patient leaflet and follow your own clinical protocols.
What is Syntometrine injection?
Syntometrine injection is a sterile injectable medicine used in obstetrics. It contains two active ingredients: ergometrine maleate and oxytocin.
According to the content provided, each 1 ml ampoule contains 500 micrograms of ergometrine and 5 IU of oxytocin. The combination is used to help the uterus contract after delivery.
What is Syntometrine used for?
Syntometrine is primarily used for:
- Active management of the third stage of labour
- Prevention of postpartum haemorrhage
- Support of uterine tone after delivery
Its role is to help the placenta be delivered and to reduce the risk of excessive bleeding after childbirth.
What are the active ingredients?
The medicine combines two uterotonic agents:
- Ergometrine maleate: Helps stimulate uterine contractions.
- Oxytocin: A hormone that increases the strength and frequency of uterine contractions.
Together, these ingredients are intended to produce a stronger uterotonic effect than either ingredient alone.
How is Syntometrine administered?
Syntometrine is typically given by intramuscular injection. The original content states that it is usually administered after delivery of the anterior shoulder during childbirth, but timing should always follow the relevant clinical guidance and the official product information.
Administration should be carried out by a healthcare professional, with appropriate monitoring before and after the injection.
Important precautions
Before use, the healthcare team should review the patient’s history and current condition. The original content highlights the need for caution in people with:
- Hypersensitivity to ergometrine, oxytocin, or any ingredient in the formulation
- Severe hypertension
- Cardiac, hepatic, or renal impairment
Extra caution is also advised in patients with moderate hypertension or other cardiovascular risk factors.
What side effects are mentioned?
The content provided lists the following common side effects:
- Nausea
- Vomiting
- Dizziness
- Headache
It also notes that blood pressure changes and more serious cardiovascular effects may be a concern in higher-risk patients. Any concerning symptoms should be assessed promptly by a healthcare professional.
Key safety points for clinicians and patients
Syntometrine should be used under medical supervision. The original content also notes the importance of checking for possible interactions with medicines that affect blood pressure.
If dizziness occurs after administration, the patient should avoid driving or operating machinery until they feel well again.
Quick reference table
| Topic | Summary |
|---|---|
| Medicine type | Combination uterotonic injection |
| Active ingredients | Ergometrine maleate and oxytocin |
| Main use | Third stage of labour and postpartum haemorrhage prevention |
| Usual route | Intramuscular injection |
| Commonly mentioned side effects | Nausea, vomiting, dizziness, headache |
FAQ
▸ What is the use of Syntometrine injection?
It is used in obstetrics for active management of the third stage of labour and to help prevent postpartum haemorrhage.
▸ Is oxytocin the same as Syntometrine?
No. Syntometrine contains oxytocin plus ergometrine maleate, so it is a combination product rather than oxytocin alone.
▸ Can Syntometrine be given IV?
The content provided states that it is primarily administered intramuscularly. Any route of administration should follow the official product information and local guidance.
▸ What side effects are mentioned for Syntometrine?
The article content mentions nausea, vomiting, dizziness, and headache, with blood pressure changes also noted as a concern.
▸ Who should be cautious with Syntometrine?
Caution is highlighted for people with hypersensitivity to the ingredients, severe hypertension, or cardiac, hepatic, or renal impairment.
Safety reminder
Always verify the latest SPC, local obstetric protocol, and patient-specific factors before use. If symptoms such as severe headache, chest pain, marked dizziness, or unusual bleeding occur after administration, urgent clinical assessment is needed.
Sources to verify
For the most accurate and up-to-date information, check the official product leaflet, the Summary of Product Characteristics, and local maternity guidelines.
Medical disclaimer
This content is for educational purposes only. It should not be used as a substitute for professional medical advice, diagnosis or treatment. Always ask a doctor, pharmacist or qualified healthcare professional before starting, stopping or changing any medicine.
Sources and verification
The following sources or official references are listed to support verification of the medicine information discussed in this article.
- Electronic Medicines Compendium (emc) - Syntometrine SPC
- NHS medicines information
- WHO recommendations on postpartum haemorrhage prevention
- Local maternity and obstetric guidelines
To improve this article with specific references, add a custom field named _aio_sources in the post editor and write one source per line using: Source title|Source URL.
Medicine information can change and may vary depending on country, product formulation, patient history and professional guidance. Always check official medicine information and ask a healthcare professional for personal medical questions.