This website provides educational information about medicines and active ingredients. It does not replace medical advice, diagnosis or treatment from a qualified healthcare professional.
Injectable Medicine

Lidocaine 1% with Adrenaline Injection: Uses and Side Effects

Quick summary Lidocaine 1% with adrenaline (epinephrine) is a local anesthetic used by healthcare professionals to numb an area, reduce pain during procedures, and help limit bleeding at the injection site. Medical disclaimer This...

Educational content Use this article as a starting point for understanding the topic.
Check with a professional Ask a doctor or pharmacist before changing any medicine.
Safety first Side effects, interactions and risks depend on each person.
Medical disclaimer

This content is for educational purposes only and does not replace medical advice, diagnosis or treatment from a qualified healthcare professional.

Quick summary

Lidocaine 1% with adrenaline (epinephrine) is a local anesthetic used by healthcare professionals to numb an area, reduce pain during procedures, and help limit bleeding at the injection site.

Medical disclaimer

This article is for general information only and does not replace advice from a qualified clinician or the official product leaflet. Lidocaine with adrenaline should only be used and monitored by trained healthcare professionals.

What is lidocaine 1% with adrenaline (epinephrine)?

Lidocaine 1% with adrenaline (epinephrine) is a combination injection used as a local anesthetic. It is designed to block pain signals in a specific area of the body during medical or dental procedures.

The adrenaline component helps narrow blood vessels at the injection site. This can help the anesthetic last longer and may reduce bleeding in the treated area.

How does it work?

Lidocaine works by blocking sodium channels in nerve cells. This prevents pain signals from traveling to the brain.

Adrenaline adds a vasoconstrictive effect, which reduces blood flow in the area. In practice, this can help keep lidocaine concentrated where it is needed for longer.

Common uses

This medicine is used in a range of clinical settings, including:

  • Dental procedures to numb a tooth or surrounding tissue
  • Minor surgical procedures such as skin biopsies or excisions
  • Regional anesthesia for selected nerve blocks
  • Procedures where limiting bleeding may be helpful

The exact use depends on the procedure, the area being treated, and the clinician’s judgment.

Possible side effects

Like all medicines, lidocaine with adrenaline can cause side effects. The original content highlights the following possible effects:

  • Allergic reactions such as rash, itching, or swelling
  • Dizziness, drowsiness, or confusion
  • Changes in heart rhythm, especially in people with existing heart conditions
  • Methemoglobinemia, a rare condition that can reduce oxygen delivery in the body

Any severe or unexpected reaction should be assessed urgently by a healthcare professional.

Precautions before use

Before receiving this injection, a patient should tell the healthcare team about:

  • Any history of heart disease
  • Liver or kidney problems
  • Allergies or previous reactions to local anesthetics
  • Other medicines being taken
  • Pregnancy or breastfeeding

Extra caution may be needed in children and older adults.

How it is given

This injection should be administered by trained healthcare professionals. The dose and technique depend on the procedure and the patient’s individual circumstances.

Typical steps include preparing a sterile environment, selecting the correct injection site, giving the injection carefully, and monitoring the patient afterwards for any immediate reaction.

Pregnancy and breastfeeding

The original content notes that lidocaine is generally considered safe in some pregnancy situations, but the decision should be made case by case. In some procedures, clinicians may consider whether lidocaine with or without adrenaline is most appropriate.

If you are pregnant or breastfeeding, the safest approach is to discuss the planned procedure and the medicine choice with the treating clinician or pharmacist.

What to verify with a clinician or pharmacist

If you have questions about this injection, it may help to confirm:

  • Why this formulation is being used for the procedure
  • Whether your medical history changes the risk profile
  • What symptoms should be reported immediately after the injection
  • Whether pregnancy, breastfeeding, or other medicines affect the plan

Frequently asked questions

▸ What is lidocaine 1% with epinephrine?

Lidocaine 1% with epinephrine is a local anesthetic combination used to numb an area for medical or dental procedures. The epinephrine helps reduce blood flow and may prolong the anesthetic effect.

▸ What is it commonly used for?

It is commonly used for dental work, minor surgical procedures, selected nerve blocks, and other procedures where local pain relief is needed.

▸ What side effects can happen?

Possible side effects mentioned in the source include allergic reactions, dizziness, drowsiness, confusion, changes in heart rhythm, and rare methemoglobinemia.

▸ Can it be used in pregnancy?

The original content says lidocaine may be considered in some pregnancy situations, but the decision should be individualized by a healthcare professional.

▸ Does it make you sleepy?

It typically does not cause sleepiness, although some people may feel dizzy or unwell after the injection.

▸ Should I tell my clinician about other medicines?

Yes. The source emphasizes sharing your medical history and current medicines before treatment, because these details may affect safety.

Safety reminder

Seek urgent medical attention if severe symptoms occur after an injection, such as trouble breathing, swelling, fainting, chest symptoms, or a sudden change in alertness. This medicine should only be used under professional supervision.

Editorial note Active Ingredients Online Editorial Team This article is prepared as educational medicine information for general readers. It is written to support understanding of active ingredients, medicine uses, possible side effects, precautions and safety-related questions.
Published: March 8, 2026 Updated: May 10, 2026 Educational content

Medical disclaimer

This content is for educational purposes only. It should not be used as a substitute for professional medical advice, diagnosis or treatment. Always ask a doctor, pharmacist or qualified healthcare professional before starting, stopping or changing any medicine.

Sources and verification

The following sources or official references are listed to support verification of the medicine information discussed in this article.

To improve this article with specific references, add a custom field named _aio_sources in the post editor and write one source per line using: Source title|Source URL.

Final note

Medicine information can change and may vary depending on country, product formulation, patient history and professional guidance. Always check official medicine information and ask a healthcare professional for personal medical questions.

See also...
Ask a Doctor Online medical questions