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Roflumilast 500 micrograms tablets: uses and side effects

Quick summary Roflumilast 500 micrograms tablets are a prescription medicine used for long-term management of COPD in adults. They are not a quick-relief treatment for sudden breathing problems. Medical disclaimer: This article is for...

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Medical disclaimer

This content is for educational purposes only and does not replace medical advice, diagnosis or treatment from a qualified healthcare professional.

Quick summary

Roflumilast 500 micrograms tablets are a prescription medicine used for long-term management of COPD in adults. They are not a quick-relief treatment for sudden breathing problems.

Medical disclaimer: This article is for general information only. It does not replace advice from a doctor, pharmacist, or the official patient leaflet. Always follow the instructions given for your own prescription.

What are roflumilast 500 micrograms tablets?

Roflumilast 500 micrograms tablets are a prescription medicine in the phosphodiesterase-4 (PDE4) inhibitor group. They are used in the long-term management of chronic obstructive pulmonary disease (COPD).

The medicine works by helping reduce inflammation in the lungs. It is intended to help lower the frequency of COPD flare-ups, rather than to relieve sudden symptoms.

Important: roflumilast is not a rescue medicine for acute breathing problems.

Brand name

The brand name mentioned in the original content is Daliresp. Brand names can vary by country, so it is sensible to check the label, box, or leaflet for the exact product supplied to you.

How is roflumilast used?

Roflumilast 500 micrograms tablets are used for long-term prevention of COPD exacerbations. The original content states that the usual approach is one tablet daily, taken consistently at the same time each day.

It is also described as a medicine that may be used alongside other COPD treatments, especially when flare-ups continue despite standard inhaler therapy.

Do not change how you take it unless a healthcare professional tells you to do so.

Possible side effects

Like all medicines, roflumilast can cause side effects. The original content lists the following common effects:

  • Diarrhea
  • Nausea
  • Weight loss
  • Headache
  • Insomnia

The original content also notes that mood changes or anxiety may occur and should be taken seriously.

If side effects are persistent, severe, or worrying, speak with a healthcare professional promptly.

Precautions before use

Before taking roflumilast, the original content highlights several points to review with a clinician:

  • Liver health: people with liver impairment may not be suitable for this medicine.
  • Mental health history: mood-related symptoms should be discussed before treatment.
  • Allergies: any allergy to roflumilast or tablet ingredients should be reported.
  • Age: it is not suitable for children, according to the original content.
  • Pregnancy and breastfeeding: safety should be checked with a healthcare professional.

Who may not be suitable?

Roflumilast is not suitable for everyone. The original content says it is intended for adults with COPD and should be avoided in people with severe liver impairment.

It also notes that people with pre-existing mental health conditions may need closer monitoring. If you take other medicines, a pharmacist or doctor should review them for possible interactions.

What to avoid or check during treatment

The original content advises caution with alcohol and with other medicines that may interact with roflumilast. It also stresses the importance of not missing doses.

If you are unsure whether a medicine, supplement, or herbal product is suitable to take with roflumilast, check with a pharmacist or doctor first.

Key points at a glance

Topic What the original content says
Use Long-term prevention of COPD flare-ups
Medicine type PDE4 inhibitor
Brand name Daliresp
Common side effects Diarrhea, nausea, weight loss, headache, insomnia
Important caution Liver problems and mood changes should be reviewed carefully

Frequently asked questions

▸ What are the benefits of roflumilast 500 micrograms tablets?

The original content says the main benefit is reducing the frequency of COPD exacerbations. It may also help improve overall quality of life in people with chronic respiratory symptoms.

▸ How should roflumilast 500 micrograms tablets be taken?

The original content says they are taken once daily, at the same time each day. The tablet should be swallowed whole. Follow the directions on your prescription or leaflet.

▸ Can roflumilast be taken with other medicines?

It may interact with some medicines, so the original content recommends reviewing all prescription medicines, over-the-counter products, and supplements with a healthcare professional.

▸ What should I avoid while taking roflumilast?

The original content advises caution with alcohol, avoiding missed doses, and checking before taking other medicines that may interact.

▸ Is roflumilast suitable for everyone with COPD?

No. The original content says it is for adults with COPD and may not be suitable for people with severe liver impairment or certain mental health concerns.

▸ What is the cost of roflumilast 500 micrograms tablets?

The original content says the cost can vary depending on insurance coverage and pharmacy pricing. A pharmacist or insurer can confirm the current price and coverage details.

Safety reminder: If you notice worsening breathing, severe side effects, or mood changes, seek medical advice promptly. For any medicine questions, check the official leaflet or speak with a qualified healthcare professional.

Editorial note Active Ingredients Online Editorial Team This article is prepared as educational medicine information for general readers. It is written to support understanding of active ingredients, medicine uses, possible side effects, precautions and safety-related questions.
Published: January 31, 2026 Updated: May 10, 2026 Educational content

Medical disclaimer

This content is for educational purposes only. It should not be used as a substitute for professional medical advice, diagnosis or treatment. Always ask a doctor, pharmacist or qualified healthcare professional before starting, stopping or changing any medicine.

Sources and verification

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Final note

Medicine information can change and may vary depending on country, product formulation, patient history and professional guidance. Always check official medicine information and ask a healthcare professional for personal medical questions.

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