BENZONATATE (Tessalon Perles): What is used for?

What is Benzonatate? Wwhat is benzonatate used for?

Benzonatate (Benzonatato) is a drug used to treat cough.
The brand names of Benzonatate in the United States are: Tessalon Perles, Tessalon.

Benzonatate Mechanism of Action (MOA)

Cough suppressant, with a central and peripheral action mechanism. It has local anaesthetic activity, which is observed on the mucous membranes during oral administration.

Therapeutic indications, uses and benefits

Dry irritative cough due to diverse causes and bronchitis of diverse etiology. Irritative cough associated with bronchopulmonary and pleuropulmonary conditions. Acute pneumonia. Bronchitis. Chronic respiratory disease (emphysema, bronchial asthma). Pleuritis. Pulmonary tuberculosis. Pneumoconiosis. Respiratory tract tumors. Cough from the common cold. Isolated cases of refractory hypoxia have been successfully managed with this medicine.

Benzonate dosage

Adults and children >10 years: 100mg/8 h. If necessary, it can be administered up to every 4 hours with a maximum of 600mg/day.
Suppositories. Children 6 to 10 years old: 1 suppository of 50 mg every 8 h.; adults and children > 6 years old: 1 suppository of 100 mg every 8 h.

Contraindications of Benzonate

Hypersensitivity to this active ingredient and/or related substances (procaine type local anesthetics); children < 6 years old

Warnings and precautions of Benzonate

Pregnancy; lactation; the safety and efficacy of Benzonatate in children < 10 years has not been established, so its use is not recommended.


Frequent use of this medicine may enhance the effects of CNS depressant medications.




It is not known whether this medicine is excreted by breast milk, so caution is advised in this case.

Adverse reactions and side effects of Benzonate

Headaches, dizziness; gastrointestinal disturbances; nasal congestion; itching, rash; hypersensitivity; numbness of mouth, tongue and pharynx.


Source: The content of this active ingredient has been written taking into account the clinical and molecular information of all medicines authorised and marketed in the United States under the Unique Ingredient Identifier (UNII) by the Substance Registration System (SRS) of the Food and Drug Administration (FDA) and the United States Pharmacopeia (USP).

In order to know in detail the information authorized by the FDA for each drug, you should consult the corresponding medication guide authorized by the FDA.


NCI Thesaurus: C28863

5/5 (4 Reviews)

Leave a Comment

2 × 1 =