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What is Dicyclomine?
Dicyclomine (Dicicloverina) is a drug used for the treatment of irritable bowel syndrome, mucosal colitis and spastic colon. The product ingredient is Dicyclomine hydrochloride (hcl).
Dicyclomine’s brand name in the United States are: Bentyl, Dibent, Dicyclocot, Bentyl Syrup.
Dicyclomine mechanism of action (MOA)
Dicyclomine relieves smooth muscle spasm of the gastrointestinal tract. Animal studies indicate that this action is achieved by two mechanisms: a specific anticholinergic effect and a direct effect on smooth muscle.
Therapeutic indications, uses and benefits of Dicyclomine
Treatment of functional disorders of the gastrointestinal tract in which there is spasm of the smooth musculature, such as irritable colon (mucosal colitis, spastic colon, irritable bowel syndrome) and spastic constipation.
Complementary treatment in organic gastrointestinal disorders. To alleviate spasm of smooth muscles, such as colitis, diverticulitis, regional enteritis, gastritis and peptic ulcer.
Dosage of Dicyclomine
The dosage must be adjusted to the individual needs of each patient.
Adults: 10 to 40 mg of dicycloverine 3 to 4 times/day. Do not exceed 160 mg of dicyclomine daily.
Contraindications of Dicyclomine
Idiosyncrasy known to dicyclomine hydrochloride; should not be used in patients with obstructive uropathy of the gastrointestinal tract, paralytic ileus, atony, intestinal, severe ulcerative colitis and myasthenia gravis; children < 12 years.
Warnings and precautions with Dicyclomine
Dicyclomine hydrochloride is contraindicated in children 12 years of age or younger; products containing dicycloverine hydrochloride should be used with caution in any patient who has glaucoma or prostatic hypertrophy (not to exceed 80 mg/day in such patients).
It should be used with caution in patients with hiatal hernia associated with reflux esophagitis because anticholinergic medications may aggravate this condition.
- Amantadine; class one antiarrhythmic agents or drugs; antihistamines; antipsychotic drugs; benzodiazepines; MAOIs; narcotic analgesics; nitrates and nitrites; sympathomimetic agents; tricyclic antidepressants.
- Anticholinergics antagonize the effects of glaucoma drugs. Anticholinergic medications in the presence of increased intraocular pressure may be risky when taken concomitantly with medications such as corticosteroids.
- Anticholinergics may affect gastrointestinal absorption of various medications such as digoxin which may result in an elevated serum concentration of digoxin. Antacids can interfere with the absorption of anticholinergics, so simultaneous use with these drugs should be avoided.
- Drugs used to treat achlorhydria and those used for gastric secretion tests may inhibit the effects of anticholinergics on the secretion of hydrochloric acid in the stomach.
- Anticholinergic drugs may antagonize the effects of drugs that alter gastrointestinal motility, such as metoclopramide.
Since the risk of teratogenicity cannot be excluded with absolute certainty for any product, the medicinal product must be used during pregnancy only when clearly indicated by the doctor.
It is not known whether dicycloverine hydrochloride is excreted in breast milk. As with other drugs, all warnings and cautions should be taken when the mother takes them during breastfeeding.
Adverse reactions and side effects of Dicyclomine
Dry mouth, thirst, fatigue, sedation, blurred vision, rashes, constipation, anorexia, nausea, vomiting, headaches, psychotic episodes, and dysuria.
⭐⭐⭐⭐⭐ VIDEO OF DICYCLOMINE / BENTYL (DRUG)
Source: The content of this active ingredient has been written taking into account the clinical and molecular information of all medicines authorised and marketed in the United States under the Unique Ingredient Identifier (UNII) by the Substance Registration System (SRS) of the Food and Drug Administration (FDA) and the United States Pharmacopeia (USP).
In order to know in detail the information authorized by the FDA for each drug, you should consult the corresponding medication guide authorized by the FDA.