Prograf 0.5mg hard capsules: SmPC summary

What Prograf 0.5mg hard capsules are used for

Prograf 0.5mg hard capsules contain tacrolimus. The medicine is mainly used to help prevent organ rejection in people who have had a transplant, including kidney, liver, and heart transplants.

Tacrolimus is an immunosuppressant. It helps reduce the activity of the immune system so that the body is less likely to attack the transplanted organ.

Important information at a glance

• Used mainly in transplant care.
• Requires regular monitoring by healthcare professionals.
• Can interact with other medicines.
• May increase the risk of infections and other side effects.

Dosage information

The dose of Prograf 0.5mg hard capsules can vary widely from person to person. It depends on factors such as the type of transplant, body weight, and overall clinical situation.

The original content notes that starting doses may differ for kidney, liver, and heart transplant patients, and that treatment is adjusted based on response and blood level monitoring.

Do not rely on a general dose guide alone. The transplant team usually determines the dose and monitors tacrolimus levels in the blood to help keep treatment within the intended range.

How tacrolimus works

Tacrolimus works by suppressing part of the immune response. The original content explains that it inhibits T-lymphocyte activation and blocks calcineurin, which reduces the production of immune signalling molecules called cytokines.

This action helps lower the chance that the immune system will reject a transplanted organ.

Possible side effects

Like all medicines, Prograf 0.5mg hard capsules can cause side effects. The original content lists the following common effects:

• Increased blood sugar levels
• Headache
• Dizziness
• Nausea
• Diarrhoea
• Constipation

It also highlights more serious risks, including:

• Increased risk of infections
• Kidney damage
• Possible lymphoma risk

If any unusual or concerning symptoms occur, the original product information indicates that medical advice should be sought promptly.

Precautions and points to check

The original content highlights several precautions that should be considered before and during treatment:

• Pregnancy and breastfeeding: use should be carefully assessed with a healthcare professional.
• Kidney problems: people with kidney issues need close monitoring.
• Infection risk: because the immune system is suppressed, exposure to illness should be taken seriously.
• Other medicines: all current medicines should be reviewed to reduce the risk of interactions.

If you are checking this medicine for a patient, the official leaflet and transplant team guidance are the best sources for interaction screening and monitoring details.

Storage information

The original content advises the following storage points:

• Store at room temperature.
• Keep away from excessive heat and moisture.
• Keep in the original packaging until use to help protect from light.
• Keep out of reach of children and pets.
• Do not use after the expiry date.

What the capsule contains

The active ingredient in Prograf 0.5mg hard capsules is tacrolimus. The original content also notes that the capsule contains other inactive ingredients that help with stability and formulation.

If a patient has a known allergy or sensitivity to any ingredient, the official product information should be checked carefully.

Frequently asked questions

Safety reminder

Prograf is a prescription immunosuppressant used in specialist care. Do not make changes to treatment based on this summary alone. Always check the official SmPC, the patient leaflet, and the transplant team’s instructions for the most accurate and current information.

Related questions about Prograf 0.5mg hard capsules

What does Prograf look like?

The original content describes Prograf 0.5mg hard capsules as gelatin capsules with identifying marks and a distinct appearance. For exact identification, check the packaging or official product information.

What are the active ingredients in Prograf?

The active ingredient is tacrolimus. The capsule may also contain inactive ingredients that support the formulation.

What is tacrolimus 0.5 mg capsules used for?

It is mainly used to prevent organ rejection in transplant patients, including those with kidney, liver, or heart transplants.

What is the composition of the capsule of tacrolimus?

The original content states that the capsule contains tacrolimus plus excipients. If ingredient sensitivity is a concern, the official leaflet should be checked.