JOSAMYCIN (Josacine): What is used for?

What is Josamycin?

Josamycin (Josamicina) is a drug used to treat infections.
The brand name of Josamycin is Josacine.

Mechanism of action (MOA)

Interferes with bacterial protein synthesis.

Therapeutic indications, uses and benefits of Josamycin

Sensitive germ infection: bronchopulmonary, stomatological, cutaneous and urogenital.


Adults: 0.5-1 g/12 h.

Children and infants: 30-50 mg/kg bw/day in 2 doses; in general, with bw ≥ 20 kg: 500 mg/12 h (increase 25 mg/12 h per kg); with bw ≥ 10 kg: 250 mg/12 h (increase 25 mg/12 h per kg); infants with bw 5 kg: 125 mg/12 h (increase 20 mg/12 h per kg).


Hypersensitivity to this medicine and other macrolides.

Severe liver failure.

Warnings and precautions with Josamycin

Mild or moderate liver failure, adjust dosage and monitor.
Risk of pseudomembranous colitis, ventricular arrhythmia, ventricular and extrasystolic tachycardia in patients with prolonged QT.

Liver failure

Contraindicated with severe liver failure. Caution with mild or moderate liver failure, adjust dosage and monitor.


  • Risk of ischemia in extremities with: ergotamine or derivatives (not recommended association).
  • Caution with: bromocriptine, warfarin, digoxin, hexobarbital, carbamazepine, disopyramide, lovastatin.
  • Diminishes effect of: penicillins and cephalosporins.
  • Increases plasma level of: cyclosporine (in case of association, adjust doses cyclosporine and renal control).
  • Increased QT or ventricular arrhythmia with: terfenadine or astemizole (avoid).
  • Possible drowsiness with: triazolam.


Non-established security, manage only if profit outweighs potential risk.


Because it passes into human breast milk, breastfeeding should be discontinued when given to breastfeeding women.

Adverse reactions and side effects of Josamycin

Occasional: rash, anorexia, nausea, vomiting, satiety, abdominal pain, diarrhea, dyspepsia.


Source: The content of this active ingredient has been written taking into account the clinical and molecular information of all medicines authorised and marketed in the United States under the Unique Ingredient Identifier (UNII) by the Substance Registration System (SRS) of the Food and Drug Administration (FDA) and the United States Pharmacopeia (USP).

In order to know in detail the information authorized by the FDA for each drug, you should consult the corresponding medication guide authorized by the FDA.


PubChem CID: 5282165
NCI Thesaurus: C83851

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