PROMETHAZINE (Phenergan): What is used for?
[toc] What is Promethazine? Promethazine is a drug used in the treatment of urticaria, conjunctivitis, allergic manifestations and nausea. The product ingredient is Promethazine hydrochloride (hcl). The brand names of promethazine are: Phenergan, Promethegan, Phenadoz,...
This content is for educational purposes only and does not replace medical advice, diagnosis or treatment from a qualified healthcare professional.
[toc]
What is Promethazine?
Promethazine is a drug used in the treatment of urticaria, conjunctivitis, allergic manifestations and nausea. The product ingredient is Promethazine hydrochloride (hcl).
The brand names of promethazine are: Phenergan, Promethegan, Phenadoz, Adgan.
Mechanism of action of Promethazine
H1 receptor antagonist, anti-allergic.
Therapeutic indications, uses and benefits of Promethazine
Symptomatic treatment of allergic manifestations: seasonal or perennial rhinitis.
Allergic conjunctivitis, angioedema, mild urticaria.
Nausea, severe and prolonged vomiting of known etiology.
Prevention and treatment of kinetic dizziness.
Promethazine Dosage
Oral:
Adults: 50-150 mg/day;
Children: 2-3 years: 2-15 mg; 3-8 years: 15-25 mg; 8-15 years: 25-50 mg; divided into several intakes.
Deep intramuscular injection in case of emergency.
Contraindications of Prometazine
- Hypersensitivity to phenothiazines. Children < 2 years old.
- Children with severe dehydration or acute illness (chickenpox, measles, CNS infection, gastroenteritis) due to risk of dystonia. Jaundice.
- Bone marrow depression.
- History of agranulocytosis with other phenothiazines.
- Risk of urinary retention due to uroprostatic problems and closed-angle glaucoma.
Warnings and precautions with Prometazine
Severe liver failure/renal failure.
A history of seizures or brain damage and a family history of sudden infant death.
Epilepsy, monitoring.
Elderly people with tendency to orthostatic hypotension and vertigo with sedation, chronic constipation (risk of paralytic ileus), eventual prostatic hypertrophy.
Cardiovascular disease.
Avoid: prolonged exposure to sunlight; risky activity in children (bicycles, swings, etc.); in children and adolescents with signs suggestive of s. Reye.
Do not delay the administration of adrenaline if necessary.
Do not use with severe vomiting without establishing a causal agent for risk of masking symptoms of appendicitis, intestinal obstruction, s. Reye.
Extreme care in intramuscular injection administration to avoid extravasation or inadvertent subcutaneous injection; never via intraarterial (risk of severe arteriospasm and gangrene), nor SC (risk of local necrosis).
Liver failure
Caution.
Kidney failure
Caution.
Interactions with Promethazine
- Sedation enhanced by: alcohol, do not associate.
- Increased risk of “torsades de pointes” with: sultoprida, do not associate.
- Central depression increased by: CNS depressants (sedatives, barbiturates, benzodiazepines, clonidine and similar, hypnotics, morphine derivatives, methadone, neuroleptics, anxiolytics).
- Increased atropine effects with: atropine and atropine substances (imipramine antidepressants, antiparkinsonian anticholinergics, atropine antispasmodics, disopyramide, phenothiazine neuroleptics).
- Reduced absorption by: antidiarrheal, antacids.
- Intramuscular: do not mix with other drugs.
Pregnancy and Promethazine
To avoid by precaution in first quarter and not to prescribe except necessity and in any case for punctual use in third quarter.
If used at the end of pregnancy, monitor the neurological and digestive function of the newborn.
Breastfeeding
Promethazine passes into breast milk. Its administration should be avoided taking into account the possibilities of sedation or paradoxical arousal of the newborn and the associated risks of sleep apnea.
Effects on driving ability
Promethazine may cause drowsiness, especially at the beginning of treatment, which may affect the ability to drive and/or operate machines.
Patients should avoid operating dangerous machinery, including automobiles, until they know how to tolerate the medication.
Adverse reactions and side effects of Promethazine
Sedation, drowsiness.
⭐⭐⭐⭐⭐ VIDEO OF PROMETHAZINE/PHENERGAN (DRUG)
Source: The content of this active ingredient has been written taking into account the clinical and molecular information of all medicines authorised and marketed in the United States under the Unique Ingredient Identifier (UNII) by the Substance Registration System (SRS) of the Food and Drug Administration (FDA) and the United States Pharmacopeia (USP).
In order to know in detail the information authorized by the FDA for each drug, you should consult the corresponding medication guide authorized by the FDA.
Resources:
UNII: FF28EJQ494
ChemIDplus
DrugPortal
PubChem CID: 4927
NCI Thesaurus: C779
Medical disclaimer
This content is for educational purposes only. It should not be used as a substitute for professional medical advice, diagnosis or treatment. Always ask a doctor, pharmacist or qualified healthcare professional before starting, stopping or changing any medicine.
Sources and verification
Medicine information can change by country, product formulation and official safety updates. For personal decisions, verify details with official medicine information and a qualified healthcare professional. These official resources can help readers check medicine safety information:
- U.S. Food and Drug Administration — Drug information and safety updates
- MedlinePlus — Medicines and supplements
- European Medicines Agency — Medicines information
- NHS — Medicines A to Z
To improve this article with specific references, add a custom field named _aio_sources in the post editor and write one source per line using: Source title|Source URL.
Medicine information can change and may vary depending on country, product formulation, patient history and professional guidance. Always check official medicine information and ask a healthcare professional for personal medical questions.