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What is Methocarbamol?
Methocarbamol (Metocarbamol) is a drug used to treat muscle spasms.
The brand names of Methocarbamol in the United States are: Robaxin, Robaxin-750.
Mechanism of action (MOA) of Methocarbamol
Muscle relaxant of central action, whose action could be due to a general depressant effect on the CNS. It blocks contracturant and painful reflexes at the level of the spinal cord synapses without affecting the muscle or the motor plaque.
Therapeutic indications, uses and benefits of Methocarbamol
Short-term symptomatic treatment of painful muscle spasms in acute musculoskeletal disorders.
Metocarbamol dosage
Oral:
Adults: 1 g-1.5 g/6 h, in severe cases a higher dose is necessary, maximum recommended dose: 8 g/day for the first 48-72 h. In the elderly: 500 mg/6 h.
Method of administration of Methocarbamol
Oral use.
Take the tablets with a glass of water.
Contraindications of Methocarbamol
- Hypersensitivity to this active ingredient.
- Coma or precoma states.
- Known cerebral pathology.
- History of seizures or epilepsy.
- Myasthenia gravis.
Warnings and precautions with Methocarbamol
- Liver failure.
- Kidney failure.
- Children < 18 years lack of data on safety and efficacy.
Liver failure
Caution.
Kidney failure
Caution.
Interactions with Metocarbamol
- Increases the effects of: CNS depressants and stimulants including alcohol, barbiturates, anesthetics, and appetite suppressants.
- Enhances effects of: anticholinergics such as atropine and some psychotropicPosology
Inhibits the effect of: pyridoestigmine bromide - Lob: interferes with the analytical valuations of 5-hydroxyindolacetic ac.
Pregnancy and Methocarbamol
Metocarbamol is not recommended for use by pregnant women or women considering becoming pregnant, particularly in the early stages of pregnancy, unless the potential benefits outweigh the possible risks of its use.
Breastfeeding
Metocarbamol and/or its metabolites have been detected in milk in dogs, however, it is not known whether metocarbamol or its metabolites are excreted by human breast milk.
Therefore, caution should be exercised when administering to breastfeeding women.
Effects on driving ability
Metocarbamol may cause drowsiness, so patients should not drive vehicles or operate machines unless they are satisfied that their mental capacity remains unchanged, especially if other medications that may also cause drowsiness are administered concomitantly.
Adverse reactions and side effects of Metocarbamol
Leucopenia; bradycardia, flushing, hypotension, syncope; diplopia, blurred vision, nystagmus; dyspepsia, nausea and vomiting, dysgeusia.
Angioneurotic edema, anaphylactic reaction, fever, headache, conjunctivitis accompanied by nasal congestion, metallic taste; jaundice (including cholestatic jaundice); nervousness, anxiety, tremor, amnesia, confusion, dizziness or lightheadedness, vertigo, drowsiness, insomnia, mild muscle incoordination, seizures (including grand mal); itching, rash, hives.
⭐⭐⭐⭐⭐ VIDEO OF METHOCARBAMOL (DRUG)
Source: The content of this active ingredient has been written taking into account the clinical and molecular information of all medicines authorised and marketed in the United States under the Unique Ingredient Identifier (UNII) by the Substance Registration System (SRS) of the Food and Drug Administration (FDA) and the United States Pharmacopeia (USP).
In order to know in detail the information authorized by the FDA for each drug, you should consult the corresponding medication guide authorized by the FDA.
Resources:
UNII: 125OD7737X
ChemIDplus
DrugPortal
PubChem CID: 4107
NCI Thesaurus: C29252