BUSPIRONE (Buspar): What is used for?

What is Buspirone?

Buspirone is an active ingredient used for the treatment of anxiety.
The product ingredient is Buspirone hydrochloride (hcl).

The brand names of Buspirone in the United States are: BuSpar and Vanspar.

Mechanism of action (MOA) of Buspirone

Anxioselective psychotropic action, relieves anxiety without producing sedation, muscle relaxation or altered wakefulness.

Therapeutic indications, uses and benefits of Buspirone

Anxiety disorder, short-term relief with or without depression.

Buspirone Dosage

Oral.

Adults: 5 mg/3 times daily, may increase by 5 mg/day every 2-3 days.
Maximum: no > 60 mg/day.
Therapeutic response 20-30 mg/day in 2-3 doses.

Contraindications

Hypersensitivity.

Warnings and Precautions with Buspirone

  • Kidney failure.
  • Liver failure.
  • Patients with a history of alcohol and drug dependence.
  • It should not be used to detoxify patients addicted to benzodiazepines.
  • It is not recommended in patients with convulsive disorders, nor concomitant treatment with MAOI.
  • Do not administer under 18 years of age.

Liver failure

Caution. The dose should be reduced.
Not recommended in severe liver failure.

Kidney failure

Caution. The dose should be reduced.
Not recommended in severe renal insufficiency.

Interactions 

  • Plasma concentration increased by: erythromycin, itraconazole, nefazodone.
  • Increased serum concentration of: haloperidol.
  • Concomitant use with: trazodone produces increased levels of SGPT.

Pregnancy and Buspirone

Lack of studies during pregnancy.
Assess risk/benefit.

Breastfeeding

Avoid. The magnitude of excretion by human milk is not known.

Effects on driving ability

Depending on the dose and individual sensitivity, may decrease attention, alter responsiveness, and produce drowsiness, amnesia, or sedation, especially at the start of treatment or after an increase in dose.

It is not advisable to drive vehicles or operate machinery whose use requires special attention or concentration, until it is proven that the ability to perform these activities is not affected.

Adverse reactions and side effects of Buspirone

  • Dizziness.
  • Drowsiness.
  • Nervousness.
  • Nausea.
  • Sweating/cold.

‚≠ź‚≠ź‚≠ź‚≠ź‚≠ź VIDEO OF BUSPIRONE/BUSPAR (DRUG)

Source: The content of this active ingredient has been written taking into account the clinical and molecular information of all medicines authorised and marketed in the United States under the Unique Ingredient Identifier (UNII) by the Substance Registration System (SRS) of the Food and Drug Administration (FDA) and the United States Pharmacopeia (USP).

In order to know in detail the information authorized by the FDA for each drug, you should consult the corresponding medication guide authorized by the FDA.

Resources:

UNII: TK65WKS8HL
ChemIDplus
DrugPortal
PubChem CID: 2477
NCI Thesaurus: C62013

 

 

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